ChemBlogs Home - Powered by Sigma-Aldrich - Last comments

In response to: Common, Difficult to Handle Reagents in Solution

I have to weigh out some POBr3 recently and it wasn't a pleasing procedure to go through. I would appreciate it if there is a solution of this reagent.

In response to: Webcast by Professor Ei-ichi Negishi on ZACA Catalysis

Thanks for your feed back. Are there any other webcast that you feel would be helpful to your research?

In response to: Webcast by Professor Ei-ichi Negishi on ZACA Catalysis

Thanks so much for putting the whole thing online. So much on the web is short little bits and pieces, it's nice to see something substantial like this.

In response to: Common, Difficult to Handle Reagents in Solution

All Pd-C dry powder catalysts should have a visible warning on the label "IGNITES METHANOL VAPORS". Unfortunately this is not widely known.

Diluted reagents:
Na dispersion in solid paraffin wax is an excellent drying agent for THF/benzophenone ketyl stills. It would be nice to have a similar dispersion with the liquid Na-K alloy in paraffin wax. (This liquid alloy is exceedingly hazardous to handle neat - it is best made in situ).

Picric acid saturated solution in ethyl acetate. (Picric acid is explosive truck-only item, it is shipped moistened with 35% water by weight).

Pre-made TLC-stain dip solutions: Cerium-ammonium-molybdate stain, anisaldehyde stain, basic permanganate stain, ninhydrin stain.

Packaging 115% polyphosphoric acid into heat-resistant containers, such as metal can or wide-mouth Pyrex glass bottle. PPA is extremely thick and needs to be heated up before the use (so that it can be poured out from the bottle. A container for PPA that could be placed into glassware drying oven the before use would be an improvement.

In response to: Synthesis of Substituted Ureas via Cross Coupling Reactions

Thanks for catching that. I will fix it right now.

In response to: Synthesis of Substituted Ureas via Cross Coupling Reactions

typo methid should be method

In response to: Common, Difficult to Handle Reagents in Solution

RC should consider 75993: Pd/C 'Moistened with water' which is much less prone to auto-igniting.

In response to: Common, Difficult to Handle Reagents in Solution

I feel its a good initiative to ask to the chemist their opinion over a blog.
These days, in our lab we are using the 10 % Pd-C for various catalytic purpose. We think if there is any innovation in handling these auto igniting materials. Please post your opinion here or mail me at @rcmishra.com.

Thanks!

In response to: MIDA Boronates Featured in Chem and Engineering News!

Actually you don't need to log in:

http://pubs.acs.org/cen/news/87/i19/8719notw6.html

In response to: In Memorial to Dr. Steven Branca

Steve was a very interesting and well respected person throughout the organization. He will be missed. I have some very funny memories of Steve as I wish I was able to get to know him more.

In response to: Blogging and Scientists

Sandy - thanks for continuing the conversation about this. The role of science blogging is ever changing. Also good to see you on Orange Island yesterday!

In response to: Imidazolylsulfonates as Alternatives to Triflates in Cross-Coupling Reactions

Thanks Chris! I have updated the link so this should now go to the correct article.

In response to: Imidazolylsulfonates as Alternatives to Triflates in Cross-Coupling Reactions

The link at the end of the text does not direct to the correct article.

In response to: New C-C bond formation method

More information is available at the following websites:
http://www.pbn.com/detail/41018.html
http://www.uri.edu/news/releases/?id=4810
http://www.chm.uri.edu/display_abstract.php?email=bdeboef&from=facres&back=Faculty%20and%20Research&this=facres.php

In response to: New C-C bond formation method

I would like to know more about this method, but where can I read about him?

In response to: Jean-Claude Bradley - Organic chemist champions open science, Web technology

Thanks for writing about us Sandy.

In response to: Organocatalytic Synthesis of Lactones from Oxacycloalkane-2-carboxaldehydes

Thanks for catching the error --- the corrected scheme is now displayed.

In response to: Organocatalytic Synthesis of Lactones from Oxacycloalkane-2-carboxaldehydes

A mistake in this page. Lactone was formed in the paper ,
but here is aldehyde.

In response to: Arylation of Pyridines and Quinolines

That is an excellent point. What I should have written is
"without prefunctionalization." I will change it. Thanks!

In response to: Arylation of Pyridines and Quinolines

One might argue that the pyridine nitrogen serves as a directing group.